Centre
for the Neurobioloy of Stress, Division of
Life Science, University of Toronto at Scarborough
416-287-7410 gurd@utsc.utoronto.ca
Effect of Stress on the
Molecular Composition of Excitatory Synapses of the Central
Nervous System
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Homepage Research Synopsis
Our research
is concerned with the effects of stress on the structure
and function of synapses of the central nervous system.
Current projects involve analysis of the effects of ischemia
and seizure activity on the phosphorylation of synaptic
proteins, including NMDA and AMPA receptors, and the consequences
of altered phosphorylation for signaling in the postsynaptic
cell. The effects of stress on molecular interactions
within the structural framework of the postsynaptic density
are also being investigated. The results of our studies
are consistent with the hypothesis that stress induced
changes in the molecular architecture of the postsynaptic
density may be critically involved in resulting neuropathology.
