Protein Structure, Folding and Design

JBB2026H

This course emphasizes basic biophysical concepts. The lectures will be geared to both generalists and specialists. Graduate students interested in general principles of protein structure, including but not limited to those specializing in folding and structure determination, are encouraged to enroll.

Recent advances have shown how a variety of different protein conformational states, including folded, dynamic, disordered, amyloid, gel, etc., can serve biological function or cause diseases. In view of this exciting development, this course has undergone a small re-organization since 2012. In addition to our emphasis on folded and unfolded structures, now we also provide necessary physical concepts for students to understand the multiplicity of conformational states available to proteins as well as examples of the functional relevance of these states.

Course Outline:
Course outline for Fall 2016

Course Next Offered

Fall 2016

Course Time and Location

Fridays
10:00am-12:00pm.
Medical Sciences Building, Room 4171

First day: Friday September 16, 2016
Last day: Friday December 9, 2016 (final exam)

Enrollment Limit

None

Method of Student Evaluation

Student presentation (25%)
Assignments (25%)
Participation (10%)
Final exam (40%)

Papers Archive

Archive of past papers for student presentations:

2012 2010 2008 2006 2004 2002 2000 2014

Coordinator

Hue Sun Chan

Hue Sun Chan

MSB 5363
1 King's College Circle
416-978-2697
chan@arrhenius.med.utoronto.ca

Julie D. Forman-Kay

Julie D. Forman-Kay

Molecular Medicine
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9713
686 Bay Street
416-813-5358
forman@sickkids.ca

Instructors

Last Updated 13 July 2016