Protein Structure, Folding and Design


This course emphasizes basic biophysical concepts. The lectures will be geared to both generalists and specialists. Graduate students interested in general principles of protein structure, including but not limited to those specializing in folding and structure determination, are encouraged to enroll.

Recent advances have shown how a variety of different protein conformational states, including folded, dynamic, disordered, amyloid, gel, etc., can serve biological function or cause diseases. In view of this exciting development, this course has undergone a small re-organization since 2012. In addition to our emphasis on folded and unfolded structures, now we also provide necessary physical concepts for students to understand the multiplicity of conformational states available to proteins as well as examples of the functional relevance of these states.

Course Outline:
Course outline for Fall 2018


Course Next Offered

Fall 2018

Course Time and Location

Location: MSB 3278 (to be confirmed)

First Day: Sep 14
Last Day: Dec 7

Enrollment Limit


Method of Student Evaluation

Student presentation (25%)
Assignments (25%)
Participation (10%)
Final exam (40%)

Papers Archive

Archive of past papers for student presentations:

2012 2010 2008 2006 2004 2002 2000 2014 2016


Hue Sun Chan

Hue Sun Chan

MSB 5207
1 King's College Circle

Julie D. Forman-Kay

Julie D. Forman-Kay

Molecular Medicine
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9713
686 Bay Street


Last Updated 5 July 2018