Protein Trafficking in the Secretory and Endocytic Pathways


This course examines the molecular details of the secretory and endocytic pathways in the cell. Some of the specific topics covered will include protein translocation into the endoplasmic reticulum (ER), chaperones and protein folding in the ER, retrotranslocation and protein degradation, the Unfolded Protein Response (UPR), vesicle biogenesis and ER to Golgi transport, regulated secretion, basic concepts in endocytosis and protein sorting in polarized cells.

Important Dates

Jan. 5 – 10:00 am  First class

Feb. 14 – 6:00 pm  Mid-Term Exam (Room 4171 MSB)

Mar. 9 – Research paper assigned for critique (in-class selection)

Apr. 8 – 11:59 pm Research paper critiques due (email submission)

April 26 – Final Exam

Intracellular Transport Pathways: Compartments of the Secretory and Endosomal Pathways in Eukaryotic Cells. Szul, T. and Sztul, E. (2011) Physiology 26:348

Course Next Offered

January 2017

Course Time and Location

Tuesday, Thursday 10 - 11am
Room 4171 Medical Sciences Building


BCH210H/242Y, BCH311H/MGY311Y/PSL350H
Minimum cGPA of 2.8 required

Enrollment Limit

Yes — 50



Method of Student Evaluation

Quizzes: 10% (due the following lecture)

Mid-term Exam: 28% (1.5 hours; short answer format)

Paper critique: 25%
- Written critique of a randomly assigned research paper (2 pages single-spaced max.)
- Summarize basic research questions addressed, experimental approaches used and main results obtained; identify some potential pitfalls of the paper and suggest potential follow-up questions and experiments

Final Exam: 37% (3 hours; short answer format)

Additional Notes and Resources

BCH444H Spring 2017 Syllabus
Including Lecture Topics and Schedule


David B. Williams

David B. Williams

Medical Sciences Building, Room 5316


Allen Volchuk

Last Updated 9 May 2017