Protein Trafficking in the Secretory and Endocytic Pathways


This course deals with the secretory and endocytic pathways of eukaryotic cells. It examines secreted and membrane proteins as they move from their site of synthesis in the endoplasmic reticulum (ER) through to the Golgi and the plasma membrane, or are sorted to intracellular organelles. The specific topics covered include protein translocation into the ER, chaperones and protein folding in the ER, retrotranslocation and protein degradation, the Unfolded Protein Response (UPR), vesicle biogenesis and ER to Golgi transport, regulated secretion, endocytosis and protein sorting in polarized cells.

Intracellular Transport Pathways: Compartments of the Secretory and Endosomal Pathways in Eukaryotic Cells. Szul, T. and Sztul, E. (2011) Physiology 26:348

Course Next Offered

January 2020

Course Time and Location

Tuesdays and Thursdays, 10:00 - 11:00 am
Medical Sciences Building, Rm 4279


BCH210H/242Y, BCH311H/MGY311Y/PSL350H
Minimum cGPA of 2.8 required

Enrollment Limit

Yes — 50



Method of Student Evaluation

Quizzes: 12%
Mid-term test: 28% (1.5 hours; short answer)
Paper critique: 25%
Final exam: 35% (3 hours; short answer)

Additional Notes and Resources

BCH444H Syllabus 2020


James M. Rini

James M. Rini

MaRS Centre, West Tower, Rm 1614
661 University Ave


Last Updated 6 January 2020