Protein Biosynthesis

BCH440H (BCH1440H)

“The life of proteins: from birth to death”

This course is presented as eight themes.

  1. Structure, assembly, and evolution of the ribosome.
  2. mRNA synthesis, maturation, and localization.
  3. Mechanisms and regulation of translation initiation.
  4. Fidelity during translation elongation.
  5. Translation termination and translation-mediated mRNA decay
  6. Nascent protein folding and molecular chaperones.
  7. Protein degradation via the ubiquitin proteasome system and autophagy.
  8. Protein aging, misfolding and disease.

In addition to the lectures, students will work in groups during tutorial sessions to interpret a recent paper related to one of the eight themes to be formally presented during regular class hours.

Bacterial Ribosome

Course Next Offered

January 2015

Prerequisites

BCH210H1/BCH242Y1;BCH311H1/MGY311Y1/CSB349H1/PSL350H1

Enrollment Limit

Yes — 45

Method of Student Evaluation

Midterm Exam (Themes 1 to 4) 30%
Final Exam (Themes 5 to 8) 30%
Student Group Presentations (2 x 14%) 28%
MIni-Critiques (6 X 2%) 12%

Protein Biosynthesis in the News

Dr. Maria Barna (Stanford) gave a great talk in Toronto in 2017. She and her colleagues are spearheading an effort to understand diversity in ribosomes and the role that plays shaping the proteome. Here is a couple of links to commentaries on her research activities.

https://www.sciencenews.org/article/not-all-cells-protein-making-machines-do-same-job

https://www.nature.com/articles/nrm.2017.62

Coordinator

John R. Glover

John R. Glover

Rm 1616 MaRS West Tower
416-200-5985
john.glover@utoronto.ca

Instructors

Last Updated 24 April 2018