Protein Biosynthesis

BCH440H (BCH1440H)

“The life of proteins: from birth to death”

This course is presented as eight themes.

  1. Structure, assembly, and evolution of the ribosome.
  2. mRNA synthesis, maturation, and localization.
  3. Mechanisms and regulation of translation initiation.
  4. Fidelity during translation elongation.
  5. Translation termination and translation-mediated mRNA decay
  6. Nascent protein folding and molecular chaperones.
  7. Protein degradation via the ubiquitin proteasome system and autophagy.
  8. Protein aging, misfolding and disease.

In addition to the lectures, students will work in groups during tutorial sessions to interpret a recent paper related to one of the eight themes to be formally presented during regular class hours.

Course Next Offered

January 2015

Prerequisites

BCH210H1/BCH242Y1;BCH311H1/MGY311Y1/CSB349H1/PSL350H1

Enrollment Limit

Yes — 45

Method of Student Evaluation

First MIdterm 33%
Final Exam 33%
Student Presentation (2 x 16%) 34%

Coordinator

John R. Glover

John R. Glover

Room 5302, Medical Sciences Building
1 King's College Circle
416-200-5985
john.glover@utoronto.ca

Last Updated 14 December 2014