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Their story was also highlighted on the Hospital for Sick Children, CBC The National and CBC News Network, and the Globe and Mail websites:
Dr. Stavroula Andreopoulos and Dr. Derek Ng were awarded a 2017-2019 Elevation Grant from the Advancing Teaching and Learning in Arts & Science (ATLAS) initiatives fund. The proposal “Visual and Interactive Media for Deeper Molecular Understanding of Enzyme Kinetics” represents the start of a long-term mutually beneficial collaboration between the Department of Biochemistry and UTM’s Biomedical Communications (BMC) program. MScBMC students will design and develop a […]
Congratulatory message from the Chair
On behalf of the entire Biochemistry Department I would like to congratulate our esteemed colleague Dr. Lewis Kay on winning the Gairdner International Award, Canada’s highest science prize. Kay’s work on the development and use of nuclear magnetic resonance (NMR) techniques for investigating molecular motion and short lived conformations in large multiprotein complexes, or ‘seeing the unseeable’ to use the vernacular, has pushed boundaries […]
Dr. Sergio Grinstein was selected by the Canadian Society for Molecular Biosciences as this year’s recipient of the Canadian Science Publishing Senior Investigator Award. He will present his award talk at the upcoming meeting of the CSMB in Ottawa in May of this year.
Researchers in Prosser Lab and Pai Lab recently published in Science on the Role of Dimer Asymmetry and Protomer Dynamics in Enzyme Catalysis.
An interaction between the respiratory enzyme fumarate reductase (Frd, also known as Complex II) and an ATPase has been identified in E. coli by the Houry lab. The research shows that the RavA ATPase, belonging to a poorly characterized but ubiquitous MoxR family of AAA+ ATPases, associates with the Frd respiratory enzyme through an adaptor, which the group named ViaA. […]
The laboratory of Dr. Oliver Ernst has used X-ray crystallography to determine the structure of a membrane protein that never left a lipid-bilayer environment (i.e., without the use of conventional detergents). The work, published in Structure and highlighted on the Journal’s cover, was led by postdoctoral fellow Dr. Jana Broecker. Polymer-bounded lipid nanodiscs were used to extract and purify membrane proteins with their surrounding lipids and allowed […]
Many bacterial pathogens modulate their hosts through complex arsenals of effector proteins that are injected into host cell during infection. Indeed, the concept that effectors target host proteins and processes to modulate their activities is central to the current molecular understanding of host-pathogen interactions. Legionella pneumophila, the causative agent of a deadly pneumonia known as Legionnaires’ disease, has over 300 effectors, which is the largest known arsenal amongst bacterial pathogens. […]
Newly made proteins which do not quite achieve the correct 3D shape in the ER are moved to the cell cytoplasm via a specific membrane pore, and broken down. Many disease causing gene mutations e.g. in cystic fibrosis, also result in misfolding of the mutant protein, and its transport though this pore, for cytoplasmic degradation. This pore is hijacked by some bacterial toxins which need to access the cytoplasm to […]
The dimeric enzyme fluoroacetate dehalogenase is one of only a handful of protein catalysts that can break the strongest bond in organic chemistry, the one between carbon and fluorine atoms, in the process transforming the highly toxic pesticide fluoroacetate into glycolate, a benign molecule. The laboratories of Emil Pai and Scott Prosser, together with the group of Régis Pomès and collaborators in the US and Japan, have […]