HIGHLIGHT

Departmental News

7 July 2020|

Message from the Chair, Justin Nodwell.


Hello all,

I hope that your returns (partial or otherwise) to lab work have gone as smoothly as possible. None of the ‘new normal’ is perfect and there are some nagging problems that are still being worked on at our various locations. But I think we all agree that it is good and necessary to have this work going again.

In the mean time here […]

Lewis Kay Elected to the U.S. National Academy of Sciences

1 May 2020|

Our esteemed colleague Lewis Kay has been elected to the National Academy of Sciences for his remarkable work on multidimensional NMR.

http://www.nasonline.org/news-and-multimedia/news/2020-nas-election.html

This is an enormous accomplishment and a rarity for scientists outside the United States (or inside the United States for that matter).

Alex Palazzo wins award for excellence in graduate teaching

2 February 2020|

Alex Palazzo was awarded a 2019-2020 Faculty of Medicine Graduate Teaching Award for Mid-Career Excellence in Graduate Teaching and Mentorship.

Professor Palazzo was one of two recipients honoured with the faculty teaching award in this category, to recognize and celebrate outstanding contributions to graduate education.  Candidates are nominated by their Graduate Unit through a student (or recent graduate) – initiated process and the awards are adjudicated by the Faculty of […]

How bacterial invaders are sensed in the gut

25 October 2019|

A new paper in the latest issue of Science describes how the bacterial-sensing proteins, NOD1/2, are recruited to the membranes of our gut cells for them to function to initiate a proper immune response. This involves the addition of a lipid, palmitoyl, to NOD1/2 by the palmitoyl-transferase ZDHHC5. Importantly variants of NOD2 that are associated with Crohn’s disease are unable to be palmitoylated.  This work involved an international collaboration […]

Angus McQuibban awarded major funding for anti-neurodegenerative diseases drug discovery by AI

24 October 2019|

Professor G. Angus McQuibban has just been awarded a $2.3-million Genome Canada grant.

The GAPP grant in a partnership with Cyclica and Rosetta Therapeutics (founded by Professors Angus McQuibban and Peter Lewis) will support drug discovery related to treating people with the long-term neurodegenerative diseases and will involve the use of artificial intelligence and machine learning. (full story here)

Red Cell Anion Exchanger Makes the Cover of Biophysical Journal

1 October 2019|

Dario De Vecchis, a post-doctoral fellow in the laboratory of Dr. Antreas Kalli at Leeds, University, in a collaborative project with Reinhart Reithmeier used molecular dynamics simulations to build the first atomic scale model of the red cell anion exchanger in a complex lipid bilayer that mimics the native membrane. This work appeared in the latest edition of the Biophyisical Journal.  The modelling revealed the dynamic nature […]

Pai lab visualize the inner workings of an enzyme

27 September 2019|

Researchers from the Emil Pai Lab in collaboration with the Miller Lab (Depts. of Chemistry and Physics, University of Toronto) have pieced together a time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. This study, published in Science, is the most detailed depiction of such a process to date.

The communication between the protein units is accomplished via a water-network somewhat akin to a […]

Lewis Kay received an honorary degree from UBC, Okanagan!

12 July 2019|

Professor Lewis Kay was awarded an honorary Doctor of Science degree from UBC, Okanagan campus, for his “pioneering research in biochemistry and nuclear magnetic resonance spectroscopy” at the 2019 Spring Convocation. Congratulations!

Click here to read the full announcement

Structure of human mitochondrial ClpP protease – drug complex gains cover of Cancer Cell

24 May 2019|

The crystal structure of ClpP protease activated by the experimental Phase 2 anti-cancer drug ONC 201, as determined by graduate student Ondrej Halgas in Emil F. Pai’s lab, was featured on the cover of the current issue (May 13th, 2019) of the journal Cancer Cell. Together with the laboratories of Walid Houry, Aaron Schimmer (Medical Biophysics) and Michael Andreeff (MD Anderson, Texas), they identified ClpP as the […]

Scott Prosser named UofT Distinguished Professor

22 May 2019|

Professor Scott Prosser has been awarded the title of UofT Distinguished Professor of Biophysical Chemistry. This award recognizes individuals with highly distinguished accomplishments who exhibit and maintain an extraordinary level of activity in their research and scholarly work, and have achieved pre-eminence in their field in line with the University’s stated objectives and emerging priorities.

Congratulations!

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1

15 May 2019|

Wael Demian from the Rotin lab at Sickkids, recently published a Cell Reports paper showing that the ion transporter NKCC1, known to regulate cell volume, forms a complex with the leucine transporter LAT1 and the Gln transporter ASCT2, and regulates mTORC1 activation via LAT1 and growth factors signaling. Thus, the work of Demian, et al. provides a long-sought link between […]

Dr. David Andrews’ latest discovery highlighted

12 April 2019|

By Matthew Pariselli

In a new eLife paper, Dr. David Andrews, a senior scientist at Sunnybrook Research Institute, and his lab show how an interaction between proteins promotes cancer cell survival.

Andrews, who is also a professor in the department of biochemistry at the University of Toronto, discovered that Bim, a pro-cell-death protein, binds to anti-cell-death proteins at two sites, rendering it “double-bolt locked.” Previously, it was thought there was […]