HIGHLIGHT

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Mapping the molecular chaperone network

4 October 2017|

Rizzolo et al. from the Houry group provided a comprehensive view of molecular chaperone function in the cell through the use of a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. The analysis revealed the presence of a large chaperone functional supercomplex, which was named the NAJ chaperone complex, encompassing Hsp40, Hsp70, Hsp90, CCT and small Hsps. Many chaperones were found […]

SickKids scientists obtain blueprint of molecular target for blood cancer and autoimmune therapies

4 October 2017|

Researchers at The Hospital for Sick Children (SickKids) have been exploring the molecular structure of immune cell components, and how gaining an understanding of their anatomical organization can help develop future targeted therapies for blood cancers and autoimmune diseases. Dr. Jean-Philippe Julien and co-authors, Dr. June Ereño-Orbea and Taylor Sicard provide the details of their study, “Molecular basis of human CD22 function and therapeutic targeting”, published October 2 in […]

How GPCRs use phosphorylation codes for arrestin recruitment

23 August 2017|

DEER spectroscopy by Ned van Eps in the Ernst lab was used to validate the crystal structure of the phosphorylated G-protein-coupled receptor (GPCR) rhodopsin in complex with arrestin. EPR measurements confirmed the location of the C-terminal tail of rhodopsin on a arrestin binding surface in a non-crystallographic environment. GPCRs are among the most important cell surface receptors controlling nearly all of our physiology. Termination of G-protein-mediated signalling by an […]

Bear Lab shows that a new Cystic Fibrosis treatment improves function from a rare CFTR mutation in patient tissue

14 July 2017|

The laboratory of Christine Bear, together with the group of Régis Pomès and collaborators at The Hospital for Sick Children and Proteostasis Therapeutics, used in silico, in vitro and ex vivo techniques to comprehensively understand the consequences of a rare Cystic Fibrosis (CF) disease-causing mutation in the CFTR gene: c.3700 A>G (ΔI1234_R1239), and subsequently develop a novel mechanism-based therapeutic strategy.

Steven Molinski, first author of the study and recent […]

Dr. Scott Prosser wins the 2017 Jeremy Knowles Award!

11 May 2017|

Dr. Scott Prosser has received the 2017 Jeremy Knowles Award of the Royal Society of Chemistry.

Read the full story: http://www.rsc.org/ScienceAndTechnology/Awards/JeremyKnowlesAward/2017-winner.asp

Howell lab deduces the mechanism of type IV pilus motors

5 May 2017|

Howell lab

The type IV pilus is a long and sturdy grappling hook that bacteria use to attach to a surface and then pull themselves closer to the surface. They are important for virulence in many pathogens, including those that cause cholera, gonorrhoea, food-borne diseases, and multi-drug resistant hospital acquired infections. The molecular mechanism of the motors involved in throwing out and pulling […]

New genetic disease discovered by Drs. Aleixo Muise and Walter Kahr

7 April 2017|

Two of Biochemistry’s professors, Drs. Aleixo Muise and Walter Kahr have discovered a brand new genetic disease through their research at the Hospital for Sick Children.

Their research article is published on Nature Communications.

Their story was also highlighted on the Hospital for Sick Children, CBC The National and CBC News Network, and the Globe and Mail websites:

http://www.sickkids.ca/AboutSickKids/Newsroom/Past-News/2017/SickKids-team-identifies-new-disease-solves-medical-mystery.html

http://www.cbc.ca/news/thenational/new-disease-discovered-1.4054061

[…]

A still image from a 3D animation depicting the molecular context and environment for kinetic phenomena.

Visual and Interactive Media for Deeper Molecular Understanding of Enzyme Kinetics

3 April 2017|

Dr. Stavroula Andreopoulos and Dr. Derek Ng were awarded a 2017-2019 Elevation Grant from the Advancing Teaching and Learning in Arts & Science (ATLAS) initiatives fund. The proposal “Visual and Interactive Media for Deeper Molecular Understanding of Enzyme Kinetics” represents the start of a long-term mutually beneficial collaboration between the Department of Biochemistry and UTM’s Biomedical Communications (BMC) program. MScBMC students will design and develop a […]

Dr. Lewis Kay named a 2017 Canada Gairdner International Award Laureate!

30 March 2017|

Congratulatory message from the Chair

On behalf of the entire Biochemistry Department I would like to congratulate our esteemed colleague Dr. Lewis Kay on winning the Gairdner International Award, Canada’s highest science prize. Kay’s work on the development and use of nuclear magnetic resonance (NMR) techniques for investigating molecular motion and short lived conformations in large multiprotein complexes, or ‘seeing the unseeable’ to use the vernacular, has pushed boundaries […]

Dr. Stavroula Andreopoulos wins 2017 Sustained Excellence and Innovation in Life Sciences Education Award

21 March 2017|

Congratulations to Dr. Stavroula Andreopoulos on receiving the 2017 Sustained Excellence and Innovation in Life Sciences Education Award.

This award will be presented at the 15th Annual Education Achievement Celebration on May 15th.

Stagljar lab reveals new interactions among GPCRs

16 March 2017|

Using the modified membrane yeast two‐hybrid (MYTH) technology, researchers from the Stagljar lab mapped membrane protein interactions for clinically important G protein coupled receptors (GPCRs).

Read the full story on Faculty of Medicine website.

Read their paper on Molecular Systems Biology.

 

Dr. Sergio Grinstein wins the 2017 Canadian Science Publishing Senior Investigator Award!

1 March 2017|

Dr. Sergio Grinstein was selected by the Canadian Society for Molecular Biosciences as this year’s recipient of the  Canadian Science Publishing Senior Investigator Award. He will present his award talk at the upcoming meeting of the CSMB in Ottawa in May of this year.