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Dysregulation of the human mitochondrial protease ClpP induces cancer cell death

4 July 2018|

Acyldepsipeptides (ADEPs) compounds have bactericidal properties via dysregulating the activity of the highly conserved tetradecameric bacterial ClpP protease. In a recent publication in Cell Chemical Biology, Keith S. Wong and co-authors from the Houry group have reported on the identification of ADEP analogs that are potent dysregulators of the human mitochondrial ClpP (HsClpP). These analogs interact with HsClpP at high affinity, causing the protease to non-specifically degrade model […]

Malaria: Cooperating antibodies enhance immune response

20 June 2018|

Source: Steve Bryson, PhD

Malaria is one of the most inflicting infectious diseases worldwide. Each year, an estimated 200 million people contract malaria and approximately 440,000 people succumb to the infectious disease.

Scientists in the Julien lab at The Hospital for Sick Children (SickKids) and their collaborators at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, have studied how the human immune system combats malaria infections. In this […]

Avoiding catastrophe: Yeast study reveals clues to maintaining genome size

11 June 2018|

By Jovana Drinjakovic

Study reveals an unexpected role for a well- known protein machinery in maintaining the correct DNA content with implications for cancer and other diseases

As cells divide, they must accurately split their DNA between the two daughter cells or risk having an uneven number of chromosomes which can lead to developmental disorders and cancer. A new Donnelly Centre study uncovers how a […]

New Tools for Biofilm Disruption

8 June 2018|

Microbial biofilms grow on biotic and abiotic surfaces. The matrix of the biofilm that the pathogen produces protects them from the host immune response and antibiotics.  This proposes a major challenge for the treatment of chronic infections. In an article published in Plos Pathogens, Dustin J. Little and Roland Pfoh (Howell lab) and co-authors demonstrate that the C-terminal domain of PgaB is a glycoside hydrolase that can hydrolyze […]

Lewis Kay wins the 2018 Gerhard Herzberg Canada Gold Medal!

2 May 2018|

Congratulations to Professor Lewis Kay for receiving the Gerhard Herzberg Gold Medal!

The full story is featured on UofT New, the Globe and Mail, and the CBC News.

Tipping Cell Signaling Pathways by Salts

11 April 2018|

Mechanistic Insights into Allosteric Regulation of the A2A Adenosine G protein-Coupled Receptor by Physiological Cations

Libin Ye1,2, Chris Neale3, Adnan Sljoka4, Brent Lyda5, Dmitry Pichugin1,2, Nobuyuki Tsuchimura4, Sacha T. Larda1,2, Régis Pomès2,6, Angel E. García3, Oliver P. Ernst2,7, Roger K. Sunahara5, R. Scott Prosser1,2,*

In a recent paper appearing in Nature Communications, Libin Ye (Prosser lab) and co-authors reveal the delicate balance between inactive states and activation intermediates by allosteric […]

Structure and Dynamics of Complexes of G Proteins and their Receptors

16 March 2018|

Ned Van Eps in the Ernst laboratory used DEER spectroscopy together with molecular modeling techniques to map the structure of a complex between a G-protein-coupled receptor (GPCR) and its G protein. A paper describing the methodology used for characterizing the binding interface of the rhodopsin–G protein complex has recently been published in PNAS. The authors discovered that the binding mode of G protein subtypes is distinct and key differences suggest […]

Quantification of the yeast proteome

19 January 2018|

The Brown lab, together with Anastasia Baryshnikova at Calico Labs, used computational analyses to normalize and convert 21 yeast protein abundance studies to the intuitive measurement of molecules per cell. They provide precise and accurate abundance measurements for greater than 90% of yeast proteins, making it the most comprehensive quantitation of the yeast proteome, and any eukaryotic cell, to date.

With this unified dataset in hand, comparative and multivariate outlier […]

Prof. Justin Nodwell elected to the American Academy of Microbiology

5 January 2018|

Professor Justin Nodwell has been elected to Fellowship in the American Academy of Microbiology.

Single molecule imaging of mRNAs by the Palazzo Lab provides new insight into Protein Synthesis in mammalian cells

3 January 2018|

The Palazzo lab, in collaboration with Jeff Chao’s lab at the Friedrich Miescher Institute for Biomedical Research in Basel Switzerland, has resolved a long standing puzzle in how cells use mRNAs to synthesize proteins as detailed in a paper published in the most recent issue of Cell Reports (Single-Molecule Quantification of Translation-Dependent Association of mRNAs with the Endoplasmic Reticulum, Cell Reports 2017, 21: 3740–3753).

Proteins can be divided […]

How RNA decay promotes transcriptional rewiring during DNA replication stress

13 December 2017|

Raphael Loll-Krippleber from the Brown lab describes how yeast cells exposed to DNA replication stress induced by the anti-cancer drug hydroxyurea use RNA decay to reprogram gene expression. Using complementary functional genomics approaches Raphael found that a specific mRNA encoding the transcriptional repressor Yox1 is degraded at P-bodies sites to prevent accumulation of the Yox1 repressor in the nucleus. Up-regulation of YOX1 expression, as observed when P-body function is […]

Cellular Signalling in Virtual Reality

4 December 2017|

Aidin Balo in the Ernst laboratory delivers seminars about the structural details of rhodopsin signalling entirely in virtual reality for large audiences at international conferences using technology developed at Autodesk Life Sciences. A paper describing the novel aspects of the tool, the Autodesk Molecule Viewer, has been published in this month’s issue of Nature Methods (publicly accessible link: http://rdcu.be/z0HH)  A story about […]