The list below is a selection of recent publications that reflect current research in the lab.

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Davidson M.B., Katou Y., Keszthelyi A., Sing T.L., Xia T., Ou J., Vaisica J.A., Thevakumaran N., Marjavaara L., Myers C.L., Chabes A., Shirahige K., Brown G.W. (2012)
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.
EMBO J: 2012 Jan 10 [Epub ahead of print]
Abstract | Full Text

Bellay J., Atluri G., Sing T.L., Toufighi K., Costanzo M., Ribeiro P.S., Pandey G., Baller J., VanderSluis B., Michaut M., Han S., Kim P., Brown G.W., Andrews B.J., Boone C., Kumar V., Myers C.L. (2011)
Putting genetic interactions in context through a global modular decomposition.
Genome Res 21: 1375-1387
Abstract | Full Text

Vaisica J.A., Baryshnikova A., Costanzo M., Boone C., Brown G.W. (2011)
Mms1 and Mms22 Stabilize the Replisome During Replication Stress.
Mol Biol Cell 22: 2396-2408
Abstract | Full Text

Baryshnikova A., Costanzo M., Kim Y., Ding .H, Koh .J, Toufighi K., Youn J.Y., Ou J., San Luis B.J., Bandyopadhyay S., Hibbs M., Hess D., Gingras A.C., Bader G.D., Troyanskaya O.G., Brown G.W., Andrews B., Boone C., Myers C.L. (2010)
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale.
Nat Methods 7: 1017-24.
Abstract | Full Text

O'Donnell L., Panier S., Wildenhain J., Tkach J.M., Al-Hakim A., Landry M.C., Escribano-Diaz C., Szilard R.K., Young J.T., Munro M., Canny M.D., Kolas N.K., Zhang W., Harding S.M., Ylanko J., Mendez M., Mullin M., Sun T., Habermann B., Datti A., Bristow R.G., Gingras A.C., Tyers M.D., Brown G.W., Durocher D. (2010)
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
Mol Cell 40: 619-31.
Abstract | Full Text

Berbenetz N., Nislow C., Brown G.W. (2010)
Diversity of Eukaryotic DNA Replication Origins Revealed by Genome-wide Analysis of Chromatin Structure.
PLoS Genetics 6: e1001092.
Abstract | Full Text

Yang J., Bachrati C.Z., Ou J., Hickson I.D., Brown G.W. (2010)
Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1.
J Biol Chem 285: 21426-36.
Abstract | Full Text

Dion B. and Brown G.W. (2009)
Comparative genome hybridization on tiling microarrays to detect aneuploidies in yeast.
Methods Mol Biol 548: 1-18.
Abstract | Full Text

Davidson M.B. and Brown G.W. (2009)
Dissecting the DNA damage response using functional genomics approaches in S. cerevisiae. DNA Repair 8: 1110-1117.
Abstract | Full Text

Yu L, Lopez A, Anaflous A, El Bali B, Hamal A, Ericson E., Heisler L.E., McQuibban A., Giaever G., Nislow C., Boone C., Brown G.W., Bellaoui M.(2008)
Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells
PLoS Genetics 4: e1000284.
Abstract | Full Text

Nagai S., Dubrana K., Tsai-Pflugfelder M., Davidson M.B., Roberts T.M., Brown G.W., Varela E., Hediger F., Gasser S.M., Krogan N.J. (2008)
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase
Science 322: 597-602
Abstract | Full Text | Faculty of 1000 Evaluation

Xu D., Guo R., Sobeck A., Bachrati C.Z., Yang J., Enomoto T., Brown G.W., Hoatlin M.E., Hickson I.D., Wang W. (2008)
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability
Genes & Development 22: 2843-2855.
Abstract | Full Text | G & D Perspective

Davidson M.B. and Brown, G.W. (2008)
The N- and C-termini of Elg1 contribute to the maintenance of genome stability
DNA Repair 7: 1221-1232.
Abstract | Full Text

Duro, E., Vaisica, J.A., Brown, G.W., Rouse, J. (2008)
Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage
DNA Repair 7: 811-818.
Abstract | Full Text

Roberts, T.M., Waris Zaidi, I., Vaisica, J.A., Peter, M., Brown, G.W. (2008)
Regulation of Rtt107 Recruitment to Stalled DNA Replication Forks by the Cullin Rtt101 and the Rtt109 Acetyltransferase
Molecular Biology of the Cell 19: 171-180
Abstract | Full Text | Faculty of 1000 Evaluation

Xu, H., Boone, C., Brown, G. W. (2007)
Genetic Dissection of Parallel Sister Chromatid Cohesion Pathways
Genetics 176: 1417-1429
Abstract | Full Text

Collins, S.R., Miller, K.M., Maas, N.L., Roguev, A., Fillingham, J., Chu, C.S., Schuldiner, M., Gebbia, M., Recht, J., Shales, M., Ding, H., Xu, H., Han, J., Ingvarsdottir, K., Cheng, B., Andrews, B., Boone, C., Berger, S.L., Hieter, P., Zhang, Z., Brown, G.W., Ingles, C.J., Emili, A., Allis, C.D., Toczyski, D.P., Weissman, J.S., Greenblatt, J.F., Krogan, N.J. (2007)
Functional Dissection of Protein Complexes Involved in Yeast Chromosome Biology Using a Genetic Interaction Map
Nature 446: 806-810
Abstract | Full Text

Yu, L., Pena Castillo, L., Mnaimneh, S., Hughes, T. R., Brown, G. W. (2006)
A Survey of Essential Gene Function in the Yeast Cell Division Cycle
Molecular Biology of the Cell 17: 4736-4747
Abstract | Full Text | Complete data set

Wu, L., Bachrati, C. Z., Ou, J., Xu, C., Yin, J., Chang, M., Wang, W., Li, L., Brown, G. W., Hickson, I.D. (2006)
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
Proc Natl Acad Sci U S A 103: 4068-4073
Abstract | Full Text

Zhang, C., Roberts, T. M., Yang, J., Desai, R., Brown,
G. W. (2006)
Suppression of Genomic Instability by SLX5 and SLX8 in Saccharomyces cerevisiae
DNA Repair 5: 336-46
Abstract | Full Text

Roberts, T. M., Kobor, M. S., Bastin-Shanower, S. A., Ii, M., Horte, S. A., Gin, J.W., Emili, A., Rine, J., Brill, S. J., Brown, G. W. (2006)
Slx4 Regulates DNA Damage Checkpoint-dependent Phosphorylation of the BRCT Domain Protein Rtt107/Esc4
Molecular Biology of the Cell 17: 539-548
Abstract | Full Text

Davierwala, A. P., Haynes, J., Li, Z., Brost, R. L., Robinson, M. D., Yu, L., Mnaimneh, S., Ding, H., Zh,u H., Chen, Y., Cheng, X., Brown, G. W., Boone, C., Andrews, B. J., Hughes, T. R. (2005)
The synthetic genetic interaction spectrum of essential genes
Nature Genetics 37: 1147-52
Abstract | Full Text

Chang, M., Bellaoui, M., Zhang, C., Desai, R., Morozov, P., Delgado-Cruzata, L., Rothstein, R., Freyer, G. A., Boone, C., and Brown, G.W. (2005)
RMI1/NCE4, a Suppressor of Genome Instability, Encodes a Member of the RecQ Helicase/Topo III Complex
EMBO Journal 24: 2024-2033
Abstract | Full Text

Suter, B., Tong, A., Chang, M., Yu, L., Brown, G.W., Boone, C., and Rine, J. (2004)
The Origin Recognition Complex Links Replication, Sister Chromatid Cohesion, and Transcriptional Silencing in Saccharomyces cerevisiae
Genetics 167: 579-591
Abstract | Full Text

Tong, A.H.Y., Lesage, G., Bader, G., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G.F., Brost, R., Chang, M., Chen, Y., Cheng, X., Chua, G., Friesen, H., Goldberg, D.S, Haynes, J., Humphries, C., He, G., Hussein, S., Ke, L., Krogan, N., Li, Z., Levinson, J.N., Lu, H., Ménard, P., Munyana, C., Parsons, A., Ryan, O., Tonikan, R., Roberts, T., Sdicu, A., Shapiro, J., Sheikh, B., Suter, B., Wong, S.L., Zhang, L.V., Zhu, H., Burd, C.G., Munro, S., Sander, C., Rine, J., Greenblatt, J., Peter, M., Bretscher, A., Bell, G., Roth, F.P., Brown, G.W., Andrews, B., Bussey, H., Boone, C. (2004)
Genetic Interaction Networks: Large-scale Mapping of Synthetic Genetic Interactions in Yeast.
Science 303: 803-813
Abstract | Full Text | Commentary

Mayer, M. L., Pot, I., Chang, M., Xu, H., Aneliunas, V., Kwok, T., Newitt, R., Aebersold, R., Boone, C., Brown, G. W., and Hieter, P. (2004)
Identification of protein complexes required for sister chromatid cohesion.
Molecular Biology of the Cell 15: 1736-1745
Abstract | Full Text

Parsons, A. B., Brost, R., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., and Boone, C. (2004)
Chemical Genomics: Integration of Chemical-Genetic and Genetic Interaction Data Links Biologically Active Compounds to Cellular Pathways and Targets.
Nature Biotechnology 22: 62-69
Abstract | Full Text | Commentary

Duncker, B.P. & Brown, G.W.(2003)
Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.
Mutation Resarch 532: 21-27
Abstract | Full Text

Bellaoui, M., Chang, M., Ou, J., Xu, H., Boone, C., and Brown, G. W. (2003)
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.
EMBO Journal 22: 4304-4313
Abstract | Full Text | Commentary in Curr. Biol.

Chang, M., Bellaoui, M., Boone, C., and Brown, G. W. (2002)
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.
Proc. Natl. Acad. Sci. USA 99: 16934-16939
Abstract | Full Text

Fung, A. D., Ou, J., Beuler, S., and Brown, G.W. (2002)
A conserved domain of S. pombe dfp1+ is uniquely required for chromosome stability following alkylation damage during S phase.
Molecular and Cellular Biology 22: 4477-90
Abstract | Full Text | Faculty of 1000 Evaluation

Brown, G. W. and Kelly, T. J. (2000)
Regulation of DNA Replication.
Annual Review of Biochemistry 69: 829-880
Abstract | Full Text