Jolyn Duan

About Jolyn Duan

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So far Jolyn Duan has created 86 blog entries.

Hot off the press!

Success After Graduate School” is NOW available.

Drs. Nana Lee and Reinhart Reithmeier are the co-authors of this guidebook for graduate professional development designed to help create the pathway to your dream career. Special thanks to Nikko Torres for his illustrations and book design work. Thank-you to all students and faculty who helped shape this creation!

22 September 2016|

Julie Forman-Kay elected as a Fellow to the Royal Society of Canada

FORMAN-KAY, Julie – Molecular Structure & Function Program, The Hospital for Sick Children, University of Toronto
Julie Forman-Kay is the foremost Canadian expert in developing and applying tools to study the structure, interactions and functions of disordered proteins of significant biomedical relevance. Her work has led to scientific understanding of the importance of disordered proteins and links their dynamic properties and biological function, providing a foundation for novel therapeutic approaches. […]

13 September 2016|

Study indicates malnutrition in children may lead to severe impairments in liver function

A group led by Peter Kim and Robert Bandsma (Paediatrics) made a breakthrough published in Journal of Cell Biology and in the Journal of Hepatology in linking peroxisome function through the gene PEX2 and the cell’s response to starvation.

Malnourished children living in the same household who are given the same food to eat sometimes have stark differences in health, leading researchers to query why some severely malnourished […]

7 September 2016|

Protein unfolding machinery visualized

Using a combined cryo-EM and solution NMR approach the laboratories of John Rubinstein and Lewis Kay have determined the structure and equilibrium distribution of two unique conformers along the ATP hydrolysis cycle of the AAA+ unfoldase VAT. The paper published in PNAS (http://www.pnas.org/content/113/29/E4190.abstract) lends insight into how this class of molecular machines are able to convert the chemical energy of ATP hydrolysis into the mechanical force required […]

9 August 2016|

Passing of Gordon Henry Dixon

We are saddened to learn of the passing of Gordon Dixon on July 24, 2016. Gordon, a very accomplished biochemist, was Associate Professor in our Department for the period 1960-63.  Gordon was most recently  Professor Emeritus of Medical Biochemistry at the University of Calgary. He served as Department Chair there for 1983-88.

“During his illustrious academic career, he was the recipient of numerous accolades and international recognition. He served as President of […]

9 August 2016|

Dr. Greg Fairn wins the 2017 Walter A. Shaw Young Investigator Award!

Dr. Greg Fairn, St. Micahel’s Hospital and Assistant Professor in the Departments of Biochemistry and Surgery, has won the 2017 Walter A. Shaw Young Investigator Award in Lipid Research from the American Society for Biochemistry and Molecular Biology. Dr. Fairn is also the first Canadian to win this award.

The award recognizes outstanding research contributions in the area of lipids by young investigators who are an Assistant professor or […]

9 August 2016|

Seeing the first steps of DNA repair

The laboratories of John Rubinstein and Frank Sicheri (Biochemistry), and Dan Durocher (Molecular Genetics) have used electron cryomicroscopy (cryo-EM) to determine the structure of the DNA-damage recognizing protein 53BP1 bound to modified nucleosome core particles. The work, published in Nature (http://www.nature.com/nature/journal/vaop/ncurrent/full/nature18951.html), was led by postdoctoral fellow Marcus Wilson and research associate Samir Benlekbir and provides the first structural insight into how dimethylation and ubiquitination of nucleosomes in […]

2 August 2016|

Undergraduate Summer Students Share their Research

Each summer, the competitive Biochemistry Summer Student Research Program provides outstanding students with the unique opportunity to engage in research throughout the department. On Thursday July 21, 2016 students were able to share their findings in an annual poster session, outlining the goals of their project and describing their results.

22 July 2016|

Andrews’ lab identifies potential new drug combinations for chronic lymphocytic leukemia

In a paper recently published in the journal Blood, Dr. David Andrews’ group used high-content screening to test 320 kinase inhibitors and identify ones that, when given in combination with venetoclax, can overcome resistance to the drug. Venetoclax inhibits the anti-apoptotic protein Bcl-2 and received breakthrough status from the U.S. Food and Drug Administration this year. It is available in the U.S. to treat patients with chronic lymphocytic […]

8 July 2016|

When molecular chaperones misbehave

Walid Houry’s group together with Simon Sharpe’s group and others at the University of Toronto unexpectedly discovered that a bacterial chaperone forms amyloids under physiologically-relevant acidic conditions at elevated temperatures. The work has been accepted in Structure. Experimental and theoretical studies revealed that the folded core of one of the domains of the chaperones is amyloidogenic and is protected by its N-terminal loop. While molecular chaperones are […]

5 July 2016|

The 66th Annual Conference of the Canadian Society of Microbiologists – a huge success!

On June 12-15, the 66th annual Canadian Society of Microbiologists led by co-chairs Trevor Moraes and Alex Ensminger was held at the University of Toronto hosted for the first time in over 30 years. CSM2016 was a resounding success with over 525 registrants the most ever recorded at a CSM conference. The conference was held on campus with >45 talks in MSB and >300 posters in Hart […]

27 June 2016|

Kelley lab screened for new pathways involved in the maintenance of mitochondrial DNA

In a paper recently published in Nature Chemical Biology, Simon Wisnovsky in Kelley laboratory describes a high-throughput screening study that leverages small-molecule probes to look for new DNA repair and replication factors in human mitochondria.  The study uncovered a DNA polymerase that is essential for mitochondrial function that had never been observed in the organelle before.  Given the importance of mitochondria as cellular energy generators and trigger points […]

6 June 2016|