Jolyn Duan

About Jolyn Duan

This author has not yet filled in any details.
So far Jolyn Duan has created 102 blog entries.

Quantification of the yeast proteome

The Brown lab, together with Anastasia Baryshnikova at Calico Labs, used computational analyses to normalize and convert 21 yeast protein abundance studies to the intuitive measurement of molecules per cell. They provide precise and accurate abundance measurements for greater than 90% of yeast proteins, making it the most comprehensive quantitation of the yeast proteome, and any eukaryotic cell, to date.

With this unified dataset in hand, comparative and multivariate outlier […]

19 January 2018|

Prof. Justin Nodwell elected to the American Academy of Microbiology

Professor Justin Nodwell has been elected to Fellowship in the American Academy of Microbiology.

5 January 2018|

Single molecule imaging of mRNAs by the Palazzo Lab provides new insight into Protein Synthesis in mammalian cells

The Palazzo lab, in collaboration with Jeff Chao’s lab at the Friedrich Miescher Institute for Biomedical Research in Basel Switzerland, has resolved a long standing puzzle in how cells use mRNAs to synthesize proteins as detailed in a paper published in the most recent issue of Cell Reports (Single-Molecule Quantification of Translation-Dependent Association of mRNAs with the Endoplasmic Reticulum, Cell Reports 2017, 21: 3740–3753).

Proteins can be divided […]

3 January 2018|

Dr. Nana Lee featured as Ask the Expert on Nature Jobs Podcast

15 December 2017|

How RNA decay promotes transcriptional rewiring during DNA replication stress

Raphael Loll-Krippleber from the Brown lab describes how yeast cells exposed to DNA replication stress induced by the anti-cancer drug hydroxyurea use RNA decay to reprogram gene expression. Using complementary functional genomics approaches Raphael found that a specific mRNA encoding the transcriptional repressor Yox1 is degraded at P-bodies sites to prevent accumulation of the Yox1 repressor in the nucleus. Up-regulation of YOX1 expression, as observed when P-body function is […]

13 December 2017|

Cellular Signalling in Virtual Reality

Aidin Balo in the Ernst laboratory delivers seminars about the structural details of rhodopsin signalling entirely in virtual reality for large audiences at international conferences using technology developed at Autodesk Life Sciences. A paper describing the novel aspects of the tool, the Autodesk Molecule Viewer, has been published in this month’s issue of Nature Methods (publicly accessible link: http://rdcu.be/z0HH)  A story about […]

4 December 2017|

Houry Lab uncovers over 1000 novel interactions of chaperones in yeast

Kamran Rizzolo, in the laboratory of Professor Walid Houry, spoke with Faculty of Medicine’s writer Jim Oldfield about his lab’s recent  Cell Reports paper on the chaperone network in yeast.

Click here to read the full story.

4 December 2017|

Crystallographers celebrate 1,000th protein structure

Scientists have solved 1,000 protein structures using data collected at the Canadian Light Source CMCF beamlines. The Canadian Light Source (CLS) is a national research facility, producing the brightest light in Canada. The Canada Foundation for Innovation, Natural Sciences and Engineering Research Council, National Research Council of Canada, Canadian Institutes of Health Research, the Government of Saskatchewan and the University of Saskatchewan fund the CLS operations, which allows hundreds […]

4 December 2017|

2017-2018 Cohort of 2nd year Biochemistry Specialists

The first half of the academic school year is almost over and the Department of Biochemistry is pleased to welcome our incoming class of 2nd year Biochemistry Specialists.  The Biochemistry Specialist program is open to a small group of high caliber students who wish to gain an in depth understanding of the molecular mechanisms at play and practice essential critical thinking […]

1 December 2017|

Dr. Reinhart Reithmeier – featured in UofT podcast, Raw Talk

Dr. Reinhart Reithmeier talks on “student engagement” on the U of T podcast Raw Talk: http://www.rawtalkpodcast.com/2017/03/10/episode-11-dr-reinhart-reithmeier/

 

 

6 November 2017|

Mapping the molecular chaperone network

Rizzolo et al. from the Houry group provided a comprehensive view of molecular chaperone function in the cell through the use of a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. The analysis revealed the presence of a large chaperone functional supercomplex, which was named the NAJ chaperone complex, encompassing Hsp40, Hsp70, Hsp90, CCT and small Hsps. Many chaperones were found […]

4 October 2017|

SickKids scientists obtain blueprint of molecular target for blood cancer and autoimmune therapies

Researchers at The Hospital for Sick Children (SickKids) have been exploring the molecular structure of immune cell components, and how gaining an understanding of their anatomical organization can help develop future targeted therapies for blood cancers and autoimmune diseases. Dr. Jean-Philippe Julien and co-authors, Dr. June Ereño-Orbea and Taylor Sicard provide the details of their study, “Molecular basis of human CD22 function and therapeutic targeting”, published October 2 in […]

4 October 2017|