Jolyn Duan

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So far Jolyn Duan has created 78 blog entries.

Researchers revisit the role of conformational dynamics and the protein ensemble in catalysis

21 February 2017|

Houry lab identifies a novel regulator of respiratory chain complexes

Graphical abstract_120616

An interaction between the respiratory enzyme fumarate reductase (Frd, also known as Complex II) and an ATPase has been identified in E. coli by the Houry lab. The research shows that the RavA ATPase, belonging to a poorly characterized but ubiquitous MoxR family of AAA+ ATPases, associates with the Frd respiratory enzyme through an adaptor, which the group named ViaA. […]

13 February 2017|

Ernst Lab discover new way to crystallize membrane proteins

The laboratory of Dr. Oliver Ernst has used X-ray crystallography to determine the structure of a membrane protein that never left a lipid-bilayer environment (i.e., without the use of conventional detergents). The work, published in Structure and highlighted on the Journal’s cover, was led by postdoctoral fellow Dr. Jana Broecker. Polymer-bounded lipid nanodiscs were used to extract and purify membrane proteins with their surrounding lipids and allowed […]

7 February 2017|

Ensminger lab discovers a class of bacterial effectors with novel regulatory activities

Many bacterial pathogens modulate their hosts through complex arsenals of effector proteins that are injected into host cell during infection. Indeed, the concept that effectors target host proteins and processes to modulate their activities is central to the current molecular understanding of host-pathogen interactions. Legionella pneumophila, the causative agent of a deadly pneumonia known as Legionnaires’ disease, has over 300 effectors, which is the largest known arsenal amongst bacterial pathogens. […]

3 February 2017|

Lingwood Lab discover new approach to rescue endogenous misfolded proteins

Newly made proteins which do not quite achieve the correct 3D shape in the ER are moved to the cell cytoplasm via a specific membrane pore, and broken down. Many disease causing gene mutations e.g. in cystic fibrosis, also result in misfolding of the mutant protein, and its transport though this pore, for cytoplasmic degradation. This pore is hijacked by some bacterial toxins which need to access the cytoplasm to […]

1 February 2017|

The roles of protein dynamics and water networks in catalysis visualized

The dimeric enzyme fluoroacetate dehalogenase is one of only a handful of protein catalysts that can break the strongest bond in organic chemistry, the one between carbon and fluorine atoms, in the process transforming the highly toxic pesticide fluoroacetate into glycolate, a benign molecule.  The laboratories of Emil Pai and Scott Prosser, together with the group of Régis Pomès and collaborators in the US and Japan, have […]

1 February 2017|

Stagljar lab map interactions between receptor tyrosine kinases (RTKs) and protein tyrosine phosphatases (PTPs)

Featured on the front page of Molecular Cell, the research led by Dr. Igor Stagljar captured and mapped interactions between receptor tyrosine kinases (RTKs) and protein tyrosine phosphatases (PTPs) in human cells, leading to new and improved cancer therapies.

Read the full story on the Faculty of Medicine and The Varsity websites.

1 February 2017|

Davidson and Maxwell help discover off-switches for CRISPR

 

Featured on the cover of Cell, Biochemistry’s Dr. Alan Davidson and Dr. Karen Maxwell helped to discover how to turn off CRISPR. Read the full story.

31 January 2017|

Biochemistry GPD featured by NSF

Our GPD program has been highlighted as one of four North American STEM professional development programs by Council of Graduate Schools/National Science Foundation in their just published report. Check out page 27!

CGS/NSF report on STEM professional development

10 January 2017|

Charles Deber wins the 2017 Merrifield Award of the American Peptide Society

Dr. Charles Deber, Senior Scientist in the Program in Molecular Structure & Function, Research Institute, Hospital for Sick Children, and Professor in the Department of Biochemistry, University of Toronto, has received the 2017 Bruce Merrifield Award of the American Peptide Society. The Award was created in 1997 in honour of Dr. R. Bruce Merrifield, who won the Nobel Prize in Chemistry in 1984. The Award is presented every two years […]

10 January 2017|

Gilbert named Canada Research Chair in Endogenous Repair

Biochemistry faculty member Penney Gilbert was named a Tier II Canada Research Chair in Endogenous Repair for her work on understanding the mechanisms that control muscle stem cell fate during skeletal muscle homeostasis and regeneration.

Read the full story:

http://www.ibbme.utoronto.ca/news/penney-gilbert-named-canada-research-chair/

http://news.engineering.utoronto.ca/two-u-t-engineering-researchers-awarded-canada-research-chairs/

https://www.utoronto.ca/news/25-top-u-t-scholars-named-canada-research-chairs

 

2 December 2016|

Proton pumping region of rotary ATPases revealed

In work led by postdoctoral fellow Mohammad T. Mazhab-Jafari, the Rubinstein laboratory used electron cryomicroscopy (cryo-EM) to determine the atomic structure of the membrane-bound region of a eukaryotic V-ATPase. This study, which was published in Nature, gives the first high-resolution structure for the membrane region of any rotary ATPase, a family of enzymes that includes proton pumping V-ATPases and proton-driven ATP synthases. The structure reveals several surprising features of […]

3 November 2016|