Jolyn Duan

About Jolyn Duan

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So far Jolyn Duan has created 129 blog entries.

SickKids-led team discovers a drug that disarms a deadly hospital superbug

In a new study that was published in Nature Communications, a team led by Roman Melnyk, Associate Professor in the Department of Biochemistry at the University of Toronto and Senior Scientist in the Molecular Medicine program at SickKids, screened thousands of small-molecule drugs to find any that might block the effects of the deadly toxins – without affecting the gut bacteria. Niclosamide, a drug that was approved decades […]

7 December 2018|

SickKids scientists and collaborators identify structure of key malaria protein with blocking antibody

SickKids scientists have taken an important step forward on the path to finding effective biomedical interventions to halt the spread of malaria, a disease that affected an estimated 216 million people worldwide in 2016 alone.

Jean-Philippe Julien, Canada Research Chair in Structural Immunology, Assistant Professor in the Departments of Biochemistry and Immunology at the University of Toronto, and Scientist in the Molecular Medicine program at SickKids, and his colleagues […]

21 November 2018|

A big Biochemistry welcome to this year’s 2nd year class of Specialists!

The Department of Biochemistry is pleased to welcome our incoming class of 2nd year Biochemistry Specialists.  The Biochemistry Specialist program is open to a small cohort of exceptional students who wish to pursue a career in research.  This year’s class has already begun their laboratory training in BCH242Y, applying their theoretical knowledge, while honing their skills in fundamental laboratory techniques.

26 October 2018|

A novel potential approach to treat cancer: Targetting NUAK2 to block oncogenic YAP/TAZ signaling during tumorigenesis

 

Time-lapse imaging of Clover-YAP WT (first movie) and 5SA (second movie) in MDA-MB231 cells. Localization of Clover-YAP WT (wild type) and 5SA (mutant at all five LATS targeting sites) was monitored before and after addition of NUAK2 specific inhibitor, WZ4003. Note that the nuclear signal is gradually lost after addition of WZ4003 in cells expressing YAP-WT but not affected in YAP-5SA. Images were captured every 10 min for 2 hours. […]

3 October 2018|

18th International Conference on Retinal Proteins

Oliver Ernst (Biochemistry and Molecular Genetics) and Leonid Brown (University of Guelph) are organizing the 18th International Conference on Retinal Proteins, 24-29 September 2018, Hockley Valley Resort, Ontario (1h northwest of Toronto). The Resort is fully booked, but day registrations are still possible to get latest insight into retinal proteins, which are key to optogenetics and understanding GPCR signaling. The conference welcomes two of the 2018 Gairdner awardees. For […]

21 September 2018|

Dr. Nana Lee participates in Stanford’s University Life Design Studio

Dr. Nana Lee was accepted as part of the University of Toronto’s team to attend the globally known Life Design Studio at Stanford University in June, 2018. Her four-day training in design thinking will be incorporated into her latest course in graduate professional development to help students use engineering design concepts toward their graduate experience and beyond.

5 September 2018|

Emil Pai Symposium and Retirement

Emil F. Pai is retiring after more than 25 years at the University of Toronto. Emil joined the Departments of Biochemistry and Medical Genetics from the Max-Planck-Institute for Medical Research in Heidelberg in 1991 as a NSERC Industrial Research Chair following a global search for a renowned protein crystallographer to nucleate structural biology at the University of Toronto. Emil was already well-known for determining the first crystal structure of […]

8 August 2018|

Five Biochemistry Graduate Students win big at the Annual 2018 American Crystallographic Association meeting

Congratulations to graduate students: Matt McCallum, Andreea Gheorghita, and Thomas Bateman for winning the Pauling Poster Prizes and Ondrej Halgas and Natalie Bamford for winning the Taylor & Francis Biomolecular Crystallography Poster Prize and the Louis Delbaere Pauling Poster Prize, respectively, at the 2018 American Crystallographic Association (ACA) meeting held at the Sheraton Hotel, Toronto, July 22-26.

A special congratulations to Andreea Gheorghita for also winning the inaugural ACA Three minute thesis competition.

27 July 2018|

Our Politicians Need to Understand Why Science Matters

Reinhart Reithmeier and Peter Love, Vice-Chair and Chair respectfully, of the Royal Canadian Institute for Science (RCIScience) published an Op-Ed piece in the July 14 issue of the Toronto Star entitled “Our Politicians Need to Understand Why Science Matters”.

The article highlights the importance of science in driving innovation, in our educational system, and in the public and political arenas.  It raises concerns about the dismissal of Ontario’s Chief […]

18 July 2018|

Molecular Dynamics of a Blood Group Antigen

In a collaborative project started during a sabbatical leave at Oxford, Reinhart Reithmeier and Antreas Kalli (Leeds) used computer simulations to characterize the dynamics of the human red blood cell anion transport protein Band 3 in a complex lipid bilayer.

The study was published on-line July 16th in PLOS Computational Biology.

The simulations showed that the signalling lipid, PIP2, binds to specific sites on the Band 3 protein, a hub […]

18 July 2018|

2018 Faculty Promotions

The following faculty members received academic promotion this year:

Congratulation to Drs. Alex Ensminger and Roman Melnyk who have been promoted to the rank of Associate Professor, Department of Biochemistry.

Also, Dr. Gregory Fairn (primary appointment: Surgery) has been promoted to Associate Professor, and Drs. Walter Kahr (primary appointment: Paediatrics) and Aleixo Muise (primary appointment: Paediatrics) have been promoted to the rank of Full Professor.

Congratulations to you […]

4 July 2018|

Dysregulation of the human mitochondrial protease ClpP induces cancer cell death

Acyldepsipeptides (ADEPs) compounds have bactericidal properties via dysregulating the activity of the highly conserved tetradecameric bacterial ClpP protease. In a recent publication in Cell Chemical Biology, Keith S. Wong and co-authors from the Houry group have reported on the identification of ADEP analogs that are potent dysregulators of the human mitochondrial ClpP (HsClpP). These analogs interact with HsClpP at high affinity, causing the protease to non-specifically degrade model […]

4 July 2018|