Alex Palazzo

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So far Alex Palazzo has created 181 blog entries.

Biochemistry Seminars are Online

Yesterday the Department had its first ever online student seminar. Nick Ostan from the Moraes lab presented his work on Lactoferin, LbpA and LbpB. This was followed by Richard Liu from the Kahr lab who spoke to us about structural studies on VPS16B and VPS33B. Despite a few technical difficulties, it was a success by all accounts.

26 March 2020|

Update of the Departmental Activities During the Covid19 Pandemic

Message from the Chair:

The Advisory Committee to the Chair (ACC)  is now meeting on a weekly basis to discuss how to manage various student needs during this disruption.

The Department is purchasing an institutional subscription that will allow multiple, simultaneous Zoom meetings. Until then I encourage faculty to sign up individually and use this platform for lab meetings as Zoom is offering its services for free. Please contact Ayesha Glover if […]

18 March 2020|

Alex Palazzo wins award for excellence in graduate teaching

Alex Palazzo was awarded a 2019-2020 Faculty of Medicine Graduate Teaching Award for Mid-Career Excellence in Graduate Teaching and Mentorship.

Professor Palazzo was one of two recipients honoured with the faculty teaching award in this category, to recognize and celebrate outstanding contributions to graduate education.  Candidates are nominated by their Graduate Unit through a student (or recent graduate) – initiated process and the awards are adjudicated by the Faculty of […]

2 February 2020|

How bacterial invaders are sensed in the gut

A new paper in the latest issue of Science describes how the bacterial-sensing proteins, NOD1/2, are recruited to the membranes of our gut cells for them to function to initiate a proper immune response. This involves the addition of a lipid, palmitoyl, to NOD1/2 by the palmitoyl-transferase ZDHHC5. Importantly variants of NOD2 that are associated with Crohn’s disease are unable to be palmitoylated.  This work involved an international collaboration […]

25 October 2019|

Angus McQuibban awarded major funding for anti-neurodegenerative diseases drug discovery by AI

Professor G. Angus McQuibban has just been awarded a $2.3-million Genome Canada grant.

The GAPP grant in a partnership with Cyclica and Rosetta Therapeutics (founded by Professors Angus McQuibban and Peter Lewis) will support drug discovery related to treating people with the long-term neurodegenerative diseases and will involve the use of artificial intelligence and machine learning. (full story here)

24 October 2019|

Red Cell Anion Exchanger Makes the Cover of Biophysical Journal

Dario De Vecchis, a post-doctoral fellow in the laboratory of Dr. Antreas Kalli at Leeds, University, in a collaborative project with Reinhart Reithmeier used molecular dynamics simulations to build the first atomic scale model of the red cell anion exchanger in a complex lipid bilayer that mimics the native membrane. This work appeared in the latest edition of the Biophyisical Journal.  The modelling revealed the dynamic nature […]

1 October 2019|

Pai lab visualize the inner workings of an enzyme

Researchers from the Emil Pai Lab in collaboration with the Miller Lab (Depts. of Chemistry and Physics, University of Toronto) have pieced together a time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. This study, published in Science, is the most detailed depiction of such a process to date.

The communication between the protein units is accomplished via a water-network somewhat akin to a […]

27 September 2019|

Biochemistry Department Retreat 2019

The 2019 Biochemistry Retreat was a huge success. Members of the department spent September 4th to the 6th up at Geneva Park where they heard talks from students, postdocs, faculty and invited speakers. In the midst of all this, department members partook in a scavenger hunt, fireside singing and other group activities. the department also distributed awards to its trainees for their accomplishments.

Here are some highlights:

Sarah Kronheim from the […]

7 September 2019|

Enzymatic Activity Regulated by Phase Separation

In the latest issue of Science the Forman-Kay lab demonstrate that as proteins transition from the bulk solution to a phase separated condensate in a test tube, this regulates their ability to affect translation and deadenylation in the same manner observed in the cell. Partitioning of components of the translational machinery away from the mRNA can block translation while the unique condensate environment can activate deadenylation.

A previous dogma […]

24 August 2019|

Lewis Kay received an honorary degree from UBC, Okanagan!

Professor Lewis Kay was awarded an honorary Doctor of Science degree from UBC, Okanagan campus, for his “pioneering research in biochemistry and nuclear magnetic resonance spectroscopy” at the 2019 Spring Convocation. Congratulations!

Click here to read the full announcement

12 July 2019|

The inaugural Proteostasis Researchers in Canada (PRinCE) symposium

The Proteostasis Researchers in Canada (PRinCE) inaugural meeting was held at the University of Toronto on June 10-11, 2019. The aim of this first symposium was to establish a network of researchers working in the field of protein homeostasis in Canada and to promote collaborations between labs working on topics relevant to proteostasis. These include (but are not limited to) protein folding, protein trafficking, protein degradation, and neurodegenerative diseases – […]

3 July 2019|

Photos from the 2019 Benjamin Schachter Event!

On May 3, 2019, over 200 faculty, alumni, students, gathered at Hart House to celebrate Dr. Benjamin Schachter’s legacy and reunite our Department in appreciation for all of our alumni. Some of the captured moments are shown below…with more photos to come.

Thank-you to all those who attended, planned, participated, and helped make this day a memorable one!

17 June 2019|