Alex Palazzo

About Alex Palazzo

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So far Alex Palazzo has created 176 blog entries.

How bacterial invaders are sensed in the gut

A new paper in the latest issue of Science describes how the bacterial-sensing proteins, NOD1/2, are recruited to the membranes of our gut cells for them to function to initiate a proper immune response. This involves the addition of a lipid, palmitoyl, to NOD1/2 by the palmitoyl-transferase ZDHHC5. Importantly variants of NOD2 that are associated with Crohn’s disease are unable to be palmitoylated.  This work involved an international collaboration […]

25 October 2019|

Angus McQuibban awarded major funding for anti-neurodegenerative diseases drug discovery by AI

Professor G. Angus McQuibban has just been awarded a $2.3-million Genome Canada grant.

The GAPP grant in a partnership with Cyclica and Rosetta Therapeutics (founded by Professors Angus McQuibban and Peter Lewis) will support drug discovery related to treating people with the long-term neurodegenerative diseases and will involve the use of artificial intelligence and machine learning. (full story here)

24 October 2019|

Red Cell Anion Exchanger Makes the Cover of Biophysical Journal

Dario De Vecchis, a post-doctoral fellow in the laboratory of Dr. Antreas Kalli at Leeds, University, in a collaborative project with Reinhart Reithmeier used molecular dynamics simulations to build the first atomic scale model of the red cell anion exchanger in a complex lipid bilayer that mimics the native membrane. This work appeared in the latest edition of the Biophyisical Journal.  The modelling revealed the dynamic nature […]

1 October 2019|

Pai lab visualize the inner workings of an enzyme

Researchers from the Emil Pai Lab in collaboration with the Miller Lab (Depts. of Chemistry and Physics, University of Toronto) have pieced together a time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. This study, published in Science, is the most detailed depiction of such a process to date.

The communication between the protein units is accomplished via a water-network somewhat akin to a […]

27 September 2019|

Lewis Kay received an honorary degree from UBC, Okanagan!

Professor Lewis Kay was awarded an honorary Doctor of Science degree from UBC, Okanagan campus, for his “pioneering research in biochemistry and nuclear magnetic resonance spectroscopy” at the 2019 Spring Convocation. Congratulations!

Click here to read the full announcement

12 July 2019|

The inaugural Proteostasis Researchers in Canada (PRinCE) symposium

The Proteostasis Researchers in Canada (PRinCE) inaugural meeting was held at the University of Toronto on June 10-11, 2019. The aim of this first symposium was to establish a network of researchers working in the field of protein homeostasis in Canada and to promote collaborations between labs working on topics relevant to proteostasis. These include (but are not limited to) protein folding, protein trafficking, protein degradation, and neurodegenerative diseases – […]

3 July 2019|

Photos from the 2019 Benjamin Schachter Event!

On May 3, 2019, over 200 faculty, alumni, students, gathered at Hart House to celebrate Dr. Benjamin Schachter’s legacy and reunite our Department in appreciation for all of our alumni. Some of the captured moments are shown below…with more photos to come.

Thank-you to all those who attended, planned, participated, and helped make this day a memorable one!

17 June 2019|

Structure of human mitochondrial ClpP protease – drug complex gains cover of Cancer Cell

The crystal structure of ClpP protease activated by the experimental Phase 2 anti-cancer drug ONC 201, as determined by graduate student Ondrej Halgas in Emil F. Pai’s lab, was featured on the cover of the current issue (May 13th, 2019) of the journal Cancer Cell. Together with the laboratories of Walid Houry, Aaron Schimmer (Medical Biophysics) and Michael Andreeff (MD Anderson, Texas), they identified ClpP as the […]

24 May 2019|

Scott Prosser named UofT Distinguished Professor

Professor Scott Prosser has been awarded the title of UofT Distinguished Professor of Biophysical Chemistry. This award recognizes individuals with highly distinguished accomplishments who exhibit and maintain an extraordinary level of activity in their research and scholarly work, and have achieved pre-eminence in their field in line with the University’s stated objectives and emerging priorities.

Congratulations!

22 May 2019|

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1

Wael Demian from the Rotin lab at Sickkids, recently published a Cell Reports paper showing that the ion transporter NKCC1, known to regulate cell volume, forms a complex with the leucine transporter LAT1 and the Gln transporter ASCT2, and regulates mTORC1 activation via LAT1 and growth factors signaling. Thus, the work of Demian, et al. provides a long-sought link between […]

15 May 2019|

Summer Student Enrichment Program in Biochemistry (SSEPB) 2019

Each year the Department of Biochemistry at the University of Toronto provides a program devoted to enriching the overall experience of undergraduate students doing research in labs over the summer. The students learn and practice communication skills through a Three-Minute Thesis competition and by presenting there work at a research poster day. The Program also features faculty speakers talking about the breadth of research interests in the Department, and have […]

13 May 2019|

Dr. David Andrews’ latest discovery highlighted

By Matthew Pariselli

In a new eLife paper, Dr. David Andrews, a senior scientist at Sunnybrook Research Institute, and his lab show how an interaction between proteins promotes cancer cell survival.

Andrews, who is also a professor in the department of biochemistry at the University of Toronto, discovered that Bim, a pro-cell-death protein, binds to anti-cell-death proteins at two sites, rendering it “double-bolt locked.” Previously, it was thought there was […]

12 April 2019|