My laboraotry is interested in understanding how intracellular signalling cascades receive and then transmit extracellular signals and thereby modulate complex biological responses. Current areas of particular interest are the TGF b , Wnt and hippo signalling pathways, whose disruption is associated with numerous human cancers. My lab is also studies the role of TGF b superfamily members in developmental processes, such as the role of nodal and activin in early mouse embryogenesis and how BMPs contribute to neuronal morphogenesis. We use mammalian cell model systems and traditional biochemical and cell biological methods, to examine how pathway disruption alters cellular processes. In addition, we use high-throughput robotics-based methods to examine the dynamics of protein-protein interactions, and to screen for alterations in signalling output using siRNA and small-molecule chemical libraries.