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Currently Funded Trainees
Students
Trainee: David Tulumello
Supervisors: Charles Deber and R. Scott Prosser
Project Title: Detergent-solubilized transmembrane segments as models of membrane protein structure
Start Date: January 1, 2010Trainee: Ellert Nichols
Supervisors: Alan Davidson and Sachdev S. Sidhu
Project Title: Design of unique protein-peptide interfaces for the identification of physiologically relevant SH3 domain binding
Start Date: January 1, 2010Trainee: Baoxu Liu
Supervisors: Claudiu Gradinaru and Patrick T. Gunning
Project Title: Single-molecule studies of novel inhibition pathways againt the oncogenic activity of STAT proteins
Start Date: January 1, 2010Trainee: Cory Mulvhill
Supervisors: Charles Deber and Christine Bear
Project Title: Sequence dependence of interhelical folding in the CFTR membrane domain
Start Date: August 1, 2009Trainee: Keith Wong
Supervisors: Walid Houry and Andrew Emili
Project Title: Characterization of the function of the RavA-ViaA novel chaperone system
Start Date: August 1, 2009Trainee: Sacha Larda
Supervisors: R. Scott Prosser and Jianjun Wang
Project Title: Tracking in vivo protein folding of the 13c-methyl tagged MESD and calmodulin by NMR
Start Date: September 1, 2009Trainee: Yuen Shek
Supervisors: Tigran Chalikian and Robert MacGregor
Project Title: Solvation of folded and unfolded proteins in binary solvents
Start Date: September 1, 2009Trainee: Jocelyn Lo
Supervisors: Christopher Yip and Scott Gray-Owen
Project Title: Single molecule studies of the CEACAM dynamics, structure, and interactions
Start Date: September 1, 2009Trainee: Greg Clark
Supervisors: Elisabeth Tillier and Walid Houry
Project Title: Missing chaperones in Mycoplasma
Start Date: October 1, 2007Trainee: Sung Lun Stephen Lin
Supervisors: Alan Davidson and Hue Sun Chan
Project Title: An in vitro and theoretical analysis of the kinetics of SH3 domain-peptide interactions
Start Date: October 1, 2007Trainee: Soyoung Lee
Supervisors: Tigran Chalikian and Robert Macgregor
Project Title: Hydration of folded and unfolded protein states
Start Date: September 1, 2006
Post-Doctoral Fellows
Trainee: Majida El Bakkouri
Supervisors: Walid Houry and Irina Gutsche
Project Title: Biochemical analysis of the bacterial acid stress response
Start Date: January 1, 2010Trainee: Aaron Kerman
Supervisors: Avi Chakrabartty and Janice Robertson
Project Title: In vivo structural biology and interactions of misfolded SOD1 in amyotrophic lateral sclerosis
Start Date: January 1, 2010
Trainee: John Holyoak
Supervisors: Régis Pomès and Gilbert Privé
Project Title: Molecular basis of solvation and reconstructive denaturation of proteins by detergents
Start Date: September 1, 2009Trainee: Ahmed Ali
Supervisors: Andrew Woolley and R.Scott Prosser
Project Title: Developing a general approach to the photo-control of protein folding/unfolding
Start Date: January 1, 2010Trainee: Pawel Stocki
Supervisors: David Williams and Kalle Gehring
Project Title: Role of cyclophilin B and its interactions with calnexin/calreticulin in glycoprotein folding within the ER
Start Date: January 1, 2010Trainee: Prerna Patel
Supervisors: Christopher Yip and Scott Gray-Owen
Project Title: Studies of CEACAM-dependant control of cell growth and dynamics
Start Date: October 1, 2009
Previous Trainees
Students
Trainee: Derek Ng
Supervisors: Charles Deber and Avi Chakrabartty
Project Title: Membrane protein folding: proteolipid protein (PL) oligomerization and helix-helix interactions
January 1, 2008 to April 30, 2009Trainee: Braden Sweeting
Supervisors: Emil Pai and Avi Chakrabartty
Project Title: Structural characterization of intermediates in the conversion of cellular to infectious PrP
October 1, 2007 to August 30, 2009Trainee: Paul Rizk
Supervisors: Julie Forman-Kay and Avi Chakrabartty
Project Title: Characterization of conversion intermediates of prion protein using biophysical methods
October 1, 2007 to March 31, 2009Trainee: Andre Pow
Supervisors: Walid A. Houry and Raymond Hui
Project Title: Structural and functional studies on ClpP from the malaria plasmodium falciparum
September 1, 2006 to March 31, 2009Trainee: Fuzhong Zhang
Supervisors: Andrew Woolley and Alan R. Davidson
Project Title: Photo-control of folding processes controlling protein-protein interactions: coiled-coils, SH3 domains and PPR
January 1, 2006 to September 30, 2009Trainee: Irina Bezsonova
Supervisors: Julie D. Forman-Kay and R. Scott Prosser
Project Title: Structural and dynamical properties of the unfolded state of
drkN SH3 using High Pressure NMR and Oxygen
May 1, 2003 to October 31, 2007Trainee: Sean Reichheld
Supervisors: Regis Pomes and Alan Davidson
Project Title: A combined computational and in vitro investigation of the effects of small molecule binding
on protein folding using the tetracycline repressor protein as a model system.
Sept. 3, 2002 to August 31, 2006Trainee: Yulia Tsitrin
Supervisors: Walid A. Houry and Emil F. Pai
Project Title: Structure Function Studies of the ClpX Chaperone System.
Sept. 1, 2003 to February 28, 2006
Post-Doctoral Fellows
Trainee: Patrik Lundstrom
Supervisors: Julie Forman-Kay and Frank Sicheri
Project Title: Structural organization of the excited, catalytically competent, state of EphB2
January 1, 2008 to February 28, 2009Trainee: Katherine Lu
Supervisors: Khosrow Adeli and Dominic Ng
Project Title: Intracellular folding: degredation, and biogenesis of apolipoprotein B
January 1, 2008 to October 31, 2008Trainee: Elliott Stollar
Supervisors: Julie Forman-Kay and Alan Davidson
Project Title: Exploration of ‘disorder-to-disorder” transistions through the analysis of multiple Abp1 SH3-target peptide complexis
January 1, 2007 to July 2007
Trainee: Allison Ferguson
Supervisors: Hue Sun Chan and Régis Pomès
Project Title: Energetic origins of order and disorder in protein folding: multiple-body interactions and solvation effects
October 15, 2006 to April 30, 2009
Trainee: Shirley Liu
Supervisors: Janice Robertson and JoAnne McLaurin
Project Title: A therapeutic vaccine for treating amyotrophic lateral sclerosis
October 1, 2006 to March 31, 2009
Trainee: Cosmin Pocanschi
Supervisors: David Williams and Lewis E. Kay
Project Title: Structural-functional studies on the ER molecular chaperones calnexin and calreticulin by nmr spectroscopy
October 1, 2006 to September 30, 2009
Trainee: Shangxi Xiao
Supervisors: Janice Robertson and Lorne Zinman
Project Title: Identification of biomarkers for the diagnosis and prognosis of amyotrophic lateral sclerosis
October 1, 2006 to April 30, 2008Trainee: Yoshito Kakihara
Supervisors: Walid A. Houry and Emil F. Pai
Project Title: The Role of the Hsp90 chaperoneo complex in gene regulation and chromatin remodeling
June 1, 2005 to May 31, 2008Trainee: Pramodh Vallurupalli
Supervisors: Lewis E. Kay and R. Scott Prosser
Project Title: NMR dynamics studies of the E coli FRE-FAD complex
Start Date: July 1, 2005 to June 30, 2008Trainee: Eftichia Alexopoulos
Supervisors: Emil F. Pai and Avi Chakrabartty
Project Title: Structural investigations of PrP(SC)-selective antibodies complexed with the infectious prion protein
August 1, 2005 to November 30, 2006Trainee: Yu Bai
Supervisors: Gerold Schmitt-Ulms and Peter St. George-Hyslop
Project Title: In Vivo analysis of the Alzheimer's Disease amyloid precursor protein complexome
February 1, 2007 to January 31, 2008Trainee: Irina Beletskaya
Supervisors: Tigran Chalikian and Robert Macgregor
Project Title: Characterization of the role of protein folding and oligomerization
in protein-DNA recognition.
May. 1, 2004 to April 30, 2007Trainee: Mikael Borg
Supervisors: Hue Sun Chan and Julie Forman-Kay
Project Title: Interactions, entropy, and cooperativity in dynamic complexes between
disordered polypeptides and folded binding domains.
November 1, 2004 to December 31, 2007Trainee: Anna Gribun
Supervisors: Walid Houry and Christopher Yip
Project Title: Molecular determinants of complex formation between ClpX ATPase and ClpP protease.
May 1, 2004 to April 30, 2007Trainee: Patricia Hernandez
Supervisors: Walid A. Houry and David B. Williams
Project Title: Analysis of human Hsp90 chaperones:
characterization of novel substrates and cofactors.
Dec. 1, 2002 to March 31, 2003Trainee: Dmitry Mikhailovich Korzhnev
Supervisors: Lewis E. Kay and Alan R. Davidson
Project Title: Development of NMR methodology for studying protein dynamics
and its application to protein folding.
April 1, 2003 to February 28, 2004 and February 1, 2006 to March 31, 2008Trainee: Monika M. Niggemann
Supervisors: David B. Williams and John R. Glover
Project Title: The peptide binding specificities of Hsp104, calnexin, and
calreticulin and their regulation by ligands.
Sept. 1, 2003 to August 31, 2005Trainee: Eli Parhad
Supervisors: Avijit Chakrabartty and David Westaway
Project Title: Design of a copper sensor protein based on red fluorescent protein from coral:
application to histopathology of prion disease, Alzheimer's disease, and ALS.
Sept. 1, 2003 to August 31, 2005Trainee: Arianna Rath
Supervisors: Charles M. Deber and Christopher Hogue
Project Title: Threshold for hydrophobic collapse in folding of globular proteins.
March 1, 2004 to February 28, 2007Trainee: Chi Ling Michael Shuen
Supervisors: John Glover and Avi Chakrabartty
Project Title: Chaperone-mediated protein disaggregation.
March 1, 2005 to February 28, 2007Trainee: Remco Sprangers
Supervisors: Lewis E. Kay and John Rubinstein
Project Title: Structure and dynamicsof the interaction between the 19S and the 20S proteasome
November 1, 2005 to February 28, 2008Trainee: Nicolas Taulier
Supervisors: Tigran V. Chalikian and Hue Sun Chan
Project Title: Volumetric characterization of protein folding and binding.
July 1, 2003 to June 30, 2006
Travel Awardees
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| 2009 |
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| Soyoung
Lee - February, 2009 Biophysical Society, Boston USA |
Dmitry
Korzhniev - April 2009 50th Experimental Magnetic Nuclear Resonance Conference Pacific Grove, California |
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| Tujin
Shi - June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Cosmin
Pocanschi - June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| Keith
Wong - June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Braden
Sweeting- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| Shek
Yuen Lai- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Derek
Ng - June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| David
Tulumello - June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Lori
Rutkevich - June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| Zhuqing
Zhang- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Amir
Mazouchi - June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| Angela
Rutledge- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Sung
Lun Lin- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| Arash
Zarrine-Afsar- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Vikram
Mulligan- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| Andrew
Beharry- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Soyoung
Lee- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
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| Mustafa
Kamani- June 2009 2009 CSBMCB Conference - Protein Folding Principles & Diseases Niagara-on-the-Lake, Ontario |
Fuzhong
Zhang - June 2009 European Symposium of the Protein Society Zurich, Switzerland |
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| Ronnie
Lum - July 2009 AAA Proteins Meeting King City, Ontario |
Angela
Yu - August 2009 IUBMB Meeting Shanghai, China |
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2008 |
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| Soyoung
Lee - January, 2008 Proteins Under Pressure Conference, Santa Fe, New Mexico |
Dmitry
Korzhniev - May, 2008 Gordon Conference on "Computational Aspects - Biomolecular NMR" Il, Ciocco, Italy |
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| Achim
Brockmeier - May, 2008 Chaperones and the Heat Shock Response, Cold Spring Harbor, NY |
Joseph
A. Marsh - May, 2008 Gordon Conference on "Computational Aspects - Biomolecular NMR" Il, Ciocco, Italy |
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| Y.Kakihara
- July 2008 Yeast Meeting, University of Toronto |
Shirley
Liu - November 2008 Society for Neuroscience, Washington, USA |
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2007 |
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| Jen
Huen - September, 2007 AAA+ ATPase Meeting, England |
Pramodh
Vallurupalli - August, 2007 TSRC workshop on protein dynamics, Denver Co. |
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| Dmitry
Korzhniev - June, 2007 NordForsk Moscow Training course - St. Petersburg, Russia |
Ally
Ferguson - June, 2007 ICTP Meeting, Trieste, Italy |
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| Artem
Badasyan - June, 2007 ICTP Meeting, Trieste, Italy |
Sarah
Rauscher - June, 2007 ICTP Meeting, Trieste, Italy |
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| Soyoung
Lee - March, 2007 Biophysics Society conference |
Ally
Ferguson - March, 2007 APS Meeting, Denver, Co |
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| Rishi
Rakhit - January, 2007 Keystone Conference, USA |
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| Joel
Watts - October, 2006 Neuroprion meeting, Torino, Italy |
Remco
Sprangers - September, 2006 Gordon Conference, France |
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| Fuzhong
Zhang - May, 2006 Canadian Society for Chemistry Conference, Halifax |
Lei Chi
- May, 2006 Canadian Society for Chemistry Conference, Halifax |
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| Ronnie
Lum - May, 2006 Molecular Chaperones and Heat Shock response, Cold Spring Harbor, NY |
Yinan
Zhang - May, 2006 Molecular Chaperones and Heat Shock response, Cold Spring Harbor, NY |
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| Irina
Bezsonova - April, 2006 Experimental NMR Conference, Asilomar, California |
Guillaume
Thibault - May, 2006 Molecular Chaperones and Heat Shock response, Cold Spring Harbor, NY |
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| Arianna
Rath - February, 2006 Biophysical Meeting, Salt Lake City, USA |
Dmytro
Korzhniev - April, 2006 Experimental Nuclear Magnetic Resonance Conference, in Asilomar, California |
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| Irina
Beletskaya - February, 2006 Biophysical Meeting, Salt Lake City, USA |
Nicolas
Taulier - February, 2006 Biophysical Meeting, Salt Lake City, USA |
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2005 |
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| Jamie
Snider - September, 2005 Sixth International Conference on AAA+ Proteins, Austria |
Sean
Reichheld,
July, 2005 Protein Society Meeting, Boston, USA |
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Jennifer Baker - July, 2005 Protein Society Meeting, Boston, USA |
Stefan Wallin - May, 2005 ICTP conference, Trieste, Italy |
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Joel Watts - April, 2005 Symposium on The New Prion Biology, Venice, Italy |
Yinan Zhang - March, 2005 CSBMCB Meeting on Cellular Dynamics, Banff, Canada |
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Johnny Tkach - March, 2005 CSBMCB Meeting on Cellular Dynamics, Banff, Canada |
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