A new paper in the latest issue of Science describes how the bacterial-sensing proteins, NOD1/2, are recruited to the membranes of our gut cells for them to function to initiate a proper immune response. This involves the addition of a lipid, palmitoyl, to NOD1/2 by the palmitoyl-transferase ZDHHC5. Importantly variants of NOD2 that are associated with Crohn’s disease are unable to be palmitoylated. This work involved an international collaboration which included the Klip, Fairn, and Muise labs from the Biochemistry Department.
News & Events
- Phase separation of macromolecules in health and disease 28 December 2020
- Message from the Chair 18 December 2020
- Oliver P. Ernst Wins the 2020 Konrad Adenauer Research Award 8 December 2020
- The Evolution of Biological Complexity from Junk 1 December 2020
- Professor Karen Maxwell wins the John C. Polanyi Award 10 November 2020
- Professor Alexio Muise, awarded the Crohn’s and Colitis Canada 2020 Research Leadership Award 8 November 2020